"It appears that pulmonary mechanics is evolutionary designed and optimised for prone position, which is the normal posture in quadrupeds" Prone position is used in operation rooms for a long time for surgical procedures on dorsal aspect of body. It has been acknowledged that respiratory and hemodynamic instability may result because of compression of chest and abdomen in prone position, which may be relieved by supporting upper chest and pelvis with padding, to facilitate free movement of anterior abdominal wall. Beneficial effect of prone position in respiratory mechanics was first proposed by Bryan in 1974. Bryan studied the effect of sedation and paralysis on diaphragm, and suggested that prone position improve dorsal lung expansion and oxygenation 1 . Few years later Piehl and Douglas separately reported that prone position dramatically improved oxygenation in ARDS patients 2,3 . But, it had to take one more decade, to understand the mechanism of prone position in
“The time may come when penicillin can be bought by anyone in the shops. Then there is the danger that the ignorant man may easily under dose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant. Here is a hypothetical illustration. Mr. X. has a sore throat. He buys some penicillin and gives himself, not enough to kill the streptococci but enough to educate them to resist penicillin. He then infects his wife. Mrs. X gets pneumonia and is treated with penicillin. As the streptococci are now resistant to penicillin the treatment fails. Mrs. X dies. Who is primarily responsible for Mrs. X’s death?” Above statement has been borrowed from the Alexander Fleming’s noble lecture delivered on December 11, 1945. [1] Fleming’s serendipitous discovery of penicillin and its therapeutic potential in treating bacterial infection was a boon to mankind. However, shortly thereafter resistance to penicillin as well other discoverd antibiotics was observed. Scie