Pathophysiology of sepsis explains that after fluid resuscitation with 20-30 ml/kg ( which is the pressure volume of intravascular space), it is unlikely that septic shock will respond to additional fluid resuscitation.
There may be transient response, as only five percent of the crystalloid will remain in the intravascular space, and rest of the fluid will accumulate in third space, giving rise to further organ damage.
Fluid resuscitation further exacerbates the deranged physiology including vasodilatation.
Multiple Clinical trials have suggested that positive fluid balance independently causes increased morbidity and mortality.
Vasopressors should not be delayed after initial fluid resuscitation with 20-30ml/kg. Thereafter further fluid boluses may be given based on dynamic parameters of fluid responsiveness.
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