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ANTIBIOTIC RESISTANCE

"The future of humanity and microbes will likely evolve...As episodes of our wits versus their genes."
             - Dr. Joshua Lederberg

ESBL ( EXTENDED SPECTRUM BETA LACTAMASES )
CRE ( CARBAPENEM RESISTANT ENTEROBACTERIACAE )
VRE ( VANCOMYCIN RESISTANT ENTEROCOCCI )
MRSA ( METHICILLIN RESISTANT STAPH. AUREUS )
VRSA ( VANCOMYCIN RESISTANT ENTEROCOCCI )

ESKAPE organisms - Enterococcus faecium, Staph. aureus,  Klebsiella pneumonae, Acinatobacter, Pseudomonas aeriginosa, Enterobacter.

No ESKAPE,  BAD BUG NO DRUG, 10×20 Initiative- IDSA: Development of 10 new drugs by 2020.

ANTIBIOTIC STEWARDSHIP : optimal Selection, Dose and Duration of antimicrobial treatment that results in best clinical outcome, for the treatment of infection, with minimal Toxicity to patient and minimal impact on subsequent Resistance.

4 D of antimicrobial therapy : Right drug, Right dose, Right duration, Deescalation.

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