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P 0.1- Predicting Weaning Success


▪Negative pressure generated during first 100 ms of an occluded inspiration,
▪Measure of neuromuscular drive to breath,
▪measure of Neurogenic drive as well as respiratory muscle power,
▪Normal value: 1.5-2.5 cm HO
▪P 0.1 > 2.5 translates to increased Neurogenic drive to breath due to increased WEB ( work of breathing),
▪Therefore high P. 1 reflects high chances of weaning failure due to respiratory muscle fatigue.

▪P. 1 < 1.5 indicates decreased Neurogenic drive or neuromuscular weakness.
▪P. 1 may be low because of high ventilator support (WOB beared by ventilator, patient being passive).

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